Education Teaching Tools Ari Helenius Research the Lit. #1
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Research the Literature on your Own
Entry of Herpes simplex virus 1 (HSV1) is complicated by the use of multiple receptors, several viral glycoproteins, and different cell type-dependent entry mechanisms. What are different attachment factors and virus receptors used by HSV1? (Hint: check the literature on “HSV and Glycosaminoglycans”)
It is known that many viruses can use different cell surface receptors to promote their uptake. What advantage might this be to the virus with regards to infection in a human host? (Hint: check the literature on “virus receptors and tropism”)
What evidence is there that influenza virus uses clathrin-mediated endocytosis for entry? Using the techniques presented for “studying virus entry” as a guide, determine what cellular factors are used by this virus during its clathrin-mediated uptake.
It was shown in the lecture that HPV16 uses filopodia to enter the cell body. Other viruses have been demonstrated to use this mechanism as well. Movement has been shown to depend on retrograde actin flow within the filopodia. What is known about the mechanisms used by viruses to associate with filopodial actin (Hint: check the literature on “viruses and filopodia”) |
