Genes that Control Aging
Part 1: It is now known that aging is not a random, inevitable process but is, instead, controlled by genetics. In this lecture, Kenyon explains how experiments in C. elegans identified the daf-2 gene (and its mamamalian homologue the insulin/IGF-1 receptor gene) as key in regulating aging. Suitable for upper level undergraduates or graduate students.

• Lecture notes
• Recommended reading
• Review questions (Answers*)
• Facilitator questions (Answers*)
• Explain/teach these concepts to a friend
• Research the literature on your own
• See Cynthia Kenyon's Seminar
• PDF of all materials
• Prepared by Cynthia Kenyon and Meredith Judy

* To view answers you must register on the site as a teacher, or if you are a student studying on your own, please This e-mail address is being protected from spambots. You need JavaScript enabled to view it with a request for the answers.

Genes that Control Aging
Part 2: This lecture is appropriate for graduate students. Kenyon discusses in greater detail the role of DAF-2/insulin/IGF-1 receptor pathway in aging in both C. elegans and mammalian systems.

• Recommended reading
• Review questions (Answers*)
• Facilitator questions (Answers*)
• Explain/teach these concepts to a friend
• Research the literature on your own
• Papers for journal club
• See Cynthia Kenyon's Seminar
• PDF of all materials
• Prepared by Cynthia Kenyon and Meredith Judy