Review Questions

Q. Why do we use C. elegans to study aging?

Q. How can we change genes in C. elegans? How can we look for gene expression changes in C. elegans?

Q. What evidence is there that aging regulation by the insulin/IGF-1 pathway is conserved across species?

Q. How does the DAF-2/insulin/IGF-1 signaling pathway work?

Q. What sorts of genes are regulated by the DAF-16 transcription factor?

Q. When does daf-2 act to regulate aging in C. elegans?

Q. What processes besides aging are regulated by the DAF-2 pathway in C. elegans?

Q. What environmental signal, mentioned in the lecture, affects aging?

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