Papers for Journal Club

• Steinman, RM; Adams, JC; Cohn, ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. J Exp Med. 1975. 141:804-820.
  
  This paper provides an historical perspective on dendritic cells and their discovery.


• Jiang, A; Bloom, O; Ono, S; Cui, W; Unternaehrer, J; Jiang, S; Whitney JA; Connolly, J; Banchereau, J; Mellman, I. Disruption of E-Cadherin-Mediated Adhesion Induces a Functionally Distinct Pathway of Dendritic Cell Maturation. Immunity. 2007. 27:610-624.
  
  Maturation of DCs is not achieved solely by encounter with a TLR agonist. Here, another mechanism of DC maturation is described.


• Trombetta, ES; Ebersold, M; Garrett, W; Pypaert, M; Mellman, I. Activation of lysosomal function during dendritic cell maturation. Science. 2003. 299:1400-1403.
  
  This paper describes in more detail the importance of lysosomal proteolysis, or the lack thereof, in MHC-II dynamics and DC function.


• Chow, A; Toomre, D; Garrett, W; Mellman, I. Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature. 2002. 418:988-994.
  
  MHC-II transport is pivotal to DC function. This paper reveals, using microscopy, how MHC-II gets to the cell surface upon maturation, despite its localization in the proteolytic lysosomes.