Facilitator Questions
- Why is it important that uniaxial stretch be used in the experiments described here?
- Hypothesize why the actin cytoskeleton reorients perpendicular to the direction of stretch.
- Why was the focal adhesion protein zyxin identified as a good candidate for a stretch sensor?
- From the stretch experiments presented, how do we know that stress fiber reorientation and reinforcement occur by two distinct pathways?
- Actin stress fibers are made from bundles of filamentous actin, which are themselves polymers of actin monomers. What are some potential molecular mechanisms by which actin stress fiber thickening could occur?
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