Cell Biology of Virus Entry, Ari Helenius

Cell Biology of Virus Entry
Ari Helenius, Feb. 2009
Insitute of Biochemistry, ETH Zurich Switzerland

Lecture Overview
Viruses are extremely simple and small yet they are responsible for many of the world’s diseases. A vVirus particlees consists of only a genome, a protein coat, or capsid and sometimes a surrounding lipid envelope. To replicate, a virus must successfully enter a host cell, uncoat its genome, and appropriate the host cell machinery to replicate its genome and produce viral proteins. Part 1 of this lecture will discuss ways in which viruses bind to the surface of host cells. Simian Virus 40 which binds to specific cell surface glycolipids, glycolipids and Human Papilloma Virus-16 which binds to sites on filoipodia, are examples of different binding mechanisms. Attachment of viruses to the plasma membrane activates cell signaling resulting in endocytosis of the viral particles. This lecture is appropriate for upper level undergraduate and graduate classes studying virology or endocytosis.
Part 1: Viruses as microscopic Trojan Horses (40:11)

Click image above to start seminar in 320x240 format
Click here to view in larger 640x480 format*
QuickTime 7 Required    *640x480 System Requirements
(there may be a few seconds delay before seminars start)

Downloads in alternative formats:
(To Save, Right Click a link below and select "Save Target/Link As")
QuickTime (101.3mb)     MP4 (99.9mb)     iPod/iPhone Video (288.9mb)
PowerPoint Slides part 1 (20.05mb)

Format Descriptions
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Part 2: Why Gene Therapy Might be a Reasonable Tool for Attacking HIV (30:19)

Part 3: Open Sesame: Cell Entry and Vaccinia Virus (30:25)

Speaker Bio    Related Articles

Lecture Overview Viruses are extremely simple and small yet they are responsible for many of the world’s diseases. A vVirus particlees consists of only a genome, a protein coat, or capsid and sometimes a surrounding lipid envelope. To replicate, a virus must successfully enter a host cell, uncoat its genome, and appropriate the host cell machinery to replicate its genome and produce viral proteins. Part 1 of this lecture will discuss ways in which viruses bind to the surface of host cells. Simian Virus 40 which binds to specific cell surface glycolipids, glycolipids and Human Papilloma Virus-16 which binds to sites on filoipodia, are examples of different binding mechanisms. Attachment of viruses to the plasma membrane activates cell signaling resulting in endocytosis of the viral particles. This lecture is appropriate for upper level undergraduate and graduate classes studying virology or endocytosis.	Part 1: Viruses as microscopic Trojan Horses (40:11) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (101.3mb) MP4 (99.9mb) iPod/iPhone Video (288.9mb) PowerPoint Slides part 1 (20.05mb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 2: Why Gene Therapy Might be a Reasonable Tool for Attacking HIV (30:19) Part 3: Open Sesame: Cell Entry and Vaccinia Virus (30:25) Speaker Bio Related Articles