Related Articles

The cell biology of apicomplexan parasites

Roos, DS. 2005. Themes and variations in apicomplexan parasite biology. Science 309:72-73. PDF

Sibley, LD. 2004. Intracellular parasite invasion strategies. Science 304:248-253. PDF

Joiner, KA & DS Roos. 2002. Secretory traffic in Toxoplasma gondii: Less is more. Journal of Cell Biology 156:1039-1050. PDF

Nishi, M, K Hu, JM Murray & DS Roos. 2008. How to build a parasite: Organellar dynamics during the cell cycle of Toxoplasma gondii. Journal of Cell Science 121:1559-1568. PDF

Discovery and characterization of the apicoplast

Köhler, S, CF Delwiche, PW Denny, LG Tilney, P Webster, RJM Wilson, JD Palmer & DS Roos. 1997. A plastid of probable green algal origin in apicomplexan parasites. Science 275:1485-1488. PDF

Roos, DS, MJ Crawford, RGK Donald, JC Kissinger, LJ Klimczak & B Striepen. 1999. Origins, targeting, and function of the apicomplexan plastid. Current Opinions in Microbiology 2:426-432. PDF

Roos, DS, MJ Crawford, RGK Donald, M Fraunholz, OS Harb, CY He, JC Kissinger, MK Shaw & B Striepen. 2002. Mining the Plasmodium genome database to define organellar function: What does the apicoplast do? Philosophical Transactions of the Royal Society of London, series B (Biological Sciences) 357:35-46. PDF

Ralph, SA, GG van Dooren, RF Waller, MJ Crawford, MJ Fraunholz, BJ Foth, CJ Tonkin, DS Roos & GI McFadden. 2004. Metabolic pathway maps and functions of the Plasmodium falciparum apicoplast. Nature Reviews in Microbiology 2:203-216. PDF

Designing & mining (pathogen) genome databases

Kissinger, JC et al. 2002. The Plasmodium genome database: Designing and mining a eukaryotic genomics resource. Nature 419:490-492. See also http://PlasmoDB.org. PDF

Bahl, A et al. 2002. PlasmoDB: The Plasmodium genome resource. An integrated database providing tools for accessing and analyzing mapping, expression and sequence data (both finished and unfinished). Nucleic Acids Research 30: D87-90. See also http://PlasmoDB.org. PDF

Tongren, JE, F Zavala, DS Roos & EM Riley. 2004. Malaria vaccines: If at first you don't succeed … . Trends in Parasitology 20:604-610. See also http://PlasmoDB.org. PDF

Aurrecoechea, C et al. 2007. ApiDB: integrated resources for the apicomplexan bioinformatics resource center. Nucleic Acids Research 35:D427-430. See also http://EuPathDB.org. PDF

Drug target discovery / Global access to genomics & bioinformatics

Roos, DS. 2001. Bioinformatics -- Trying to swim in a sea of data. Science 291: 1260-1261. PDF

deGrave, W, C Huynh, DS Roos, A Oduola & CM Morel. 2002. Bioinformatics for disease endemic countries: Opportunities and challenges in science and technology development for health. IUPAC Journal. PDF

Chaudhary, K & DS Roos. 2005. Protozoan genomics for drug discovery. Nature Biotechnology 23:1089-1091. See also http://OrthoMCL.org. PDF

Agüero, F et al. 2008. Genomic-scale prioritization of drug targets. Nature Drug Discovery, in press. See also http://TDRtargets.org.

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